As mentioned above, an ongoing national phase 3 trial will compare TCD with the CliniMACS CD34 Reagent System to post-transplant cyclophosphamide [49], and a control arm (tacrolimus and methotrexate) in patients with acute leukemia and MDS who are eligible for a MAC transplant from a matched related or unrelated donor (BMT CTN 1301). Here, CD34 is linked to myelodysplastic syndrome.