Table 1 depicts the common HPV-related malignancies in HIV-positive and -negative patients. In a multivariate analysis, low CD4+ counts (≤200 cells/μL) were shown to be the strongest independent predictor of infection with high-risk HPV genotypes and genital warts [72]. Furthermore, HIV-positive patients with genital warts have greater resistance to standard treatment and HIV-positive women being treated for CIN are more likely to relapse, as compared to the general population [72,73]. Here, CD4 is linked to anogenital human papillomavirus infection.