In July 2012, the European Commission approved the addition of everolimus (EVE) to the aromatase inhibitor exemestane (EXE) for the treatment of post-menopausal women with HR+/HER2- advanced BC progressing on nonsteroidal aromatase inhibitors (NSAI: i.e. anastrozole, letrozole). Here, CYP19A1 is linked to breast cancer.