TNF and acute liver failure: Necroptosis has been indicated in injured cells in tumor necrosis factor (TNF)-induced murine fibrosarcoma L929 cells [26], TNF-induced tubular epithelial cells of donor kidneys [27], pathogenic free-living Naegleria fowleri-induced Jurkat T cells [28], TNF-related apoptosis-inducing ligand (TRAIL)-induced HepG2 cells [29], and acetaminophen-induced acute liver failure, to name a few [30].