According to the median ratio of relative SPRY4-IT1 expression (0.535), the 61 gastric cancer patients were classified into two groups: relative high-SPRY4-IT1 group (n = 30, SPRY4-IT1 expression ratio ≥ median ratio) and relative low-SPRY4-IT1 group (n = 31, SPRY4-IT1 expression ratio ≤ median ratio) (Fig. 1b). Here, SPRY4 is linked to gastric cancer.