A similar trend was seen in the fully adjusted model, with each two-fold higher plasma Lp(a) level holding a strong association with a decrease in eGFR by 0.50 mL/min/1.73 m2 (P < 0.001) per year after adjusting for demographic factors, baseline serum creatinine, BMI, hypertension, lipid-lowering medications, smoking status, alcohol use, hemoglobin A1c, and urinary ACR (Model 3). The gene discussed is LPA; the disease is hypertensive disorder.