TIMP3 and Familial drusen: For example: Sorsby fundus dystrophy may be caused by deposition of abnormal extracellular protein (TIMP-3); Doyne honeycomb retinal dystrophy may be related to activation of unfolded protein response due to misfolded fibulin-3 (EFEMP-1); and late-onset retina degeneration may be associated with abnormal intracellular protein aggregates, as well as extracellular deposition [78,79,80,81].