Several cytogenetic [12,13], molecular genetic (e.g., Fms-Like Tyrosine kinase-3 (FLT3), nucleophosmin 1 (NPM1), CCAAT enhancer-binding protein-α (CEBPA)) [14], and epigenetic changes [15], as well as aberrantly expressed RNA, and microRNA [16] have been identified as prognostic markers for disease outcome, and as shown in other hematological malignancies it is thought that some of these changes represent feasible therapy targets. Here, FLT3 is linked to hematologic disorder.