NPM1 and hematologic disorder: Several cytogenetic [12,13], molecular genetic (e.g., Fms-Like Tyrosine kinase-3 (FLT3), nucleophosmin 1 (NPM1), CCAAT enhancer-binding protein-α (CEBPA)) [14], and epigenetic changes [15], as well as aberrantly expressed RNA, and microRNA [16] have been identified as prognostic markers for disease outcome, and as shown in other hematological malignancies it is thought that some of these changes represent feasible therapy targets.