APOE and Alzheimer disease: Genetic factors account for approximately 80% of the risk for AD, and genome-wide association studies (GWAS) have identified several candidate genes besides APOE that may be associated with late-onset disease, including ABCA7, BIN1, CD33, CLU, CR1, CD2AP, EPHA1, MS4A6A-MS4A4E, PICALM, HLA-DRB5-DRB1, SORL1, FERMT2, CASS4, PTK2B, amongst others [6,7,8,9,10].