In contrast to the above findings in ACS patients, high serum concentrations of sCD40L were not associated with an increased risk of ischemic stroke or coronary events in a nested case-control study including 233 stable patients with CAD, who subsequently developed MACE, and 233 age- and gender-matched CAD patients without ischemic events [34]. The gene discussed is CD40LG; the disease is coronary artery disorder.