Gaillard et al. [64] found that 33% of nondiabetic healthy African American women were insulin sensitive and constituted MHO while 67% had insulin resistance and constituted the MUHO, based on our empirical definition of insulin resistance (Si) of ≥2.7 and <2.7 (×10−4 × min−1(μU/mL)−1), respectively. This evidence concerns the gene INS and Insulin resistance.