Pro-inflammatory cytokine expression is under the control of the ubiquitous and inducible transcription factor, NF-κB (nuclear factor-kappa B), which is activated by a variety of pathological stimuli, such as inflammatory cytokines, hyperglycemia, elevated free fatty acid levels in plasma, oxidative stress, angiotensin II, lipoproteins and anoxia [152,153]. The gene discussed is AGT; the disease is Hyperglycemia.