Mutations in the appetite-regulating hormones (e.g., leptin and proopiomelanocortin) and their corresponding receptors (e.g., leptin receptor and melanocortin 4 receptor, respectively) result in early onset of obesity and obesity-associated metabolic dysregulation in both humans and experimental rodent models [6]. Here, LEPR is linked to obesity due to melanocortin 4 receptor deficiency.