The most extensive results come from a paper by Whitehead et al. [48] where a correlation between mRNA found in maternal blood encoded by growth genes (IGF1, IGF2), IGF1R, IGFBP2, GH2, ADAM12 and the severity of disease, in severe preterm IUGR, has been demonstrated. The gene discussed is IGFBP2; the disease is fetal growth restriction.