Although these markers do not show as high sensitivity and specificity as other diagnostic IHC basal cell markers such as TP63 or antibodies detecting high molecular weight cytokeratins (34βE12) at identifying benign glands, we have shown that these markers are specific for benign prostate epithelium and speculate that based on previously reported serum analysis in combination with our findings that ACOXL could be leaked into serum during tumor growth, yielding a potential marker for prostate cancer screening. The gene discussed is ACOXL; the disease is Familial prostate cancer.