The most interesting finding in this study was the identification of two novel, uncharacterized genes in prostate from the “group enriched” category, TMEM79 and ACOXL. Both genes showed excellent protein and RNA correlation and differential protein expression in benign and prostate tissue and, thus, were chosen to be further evaluated on a larger cohort of prostate cancer cases to investigate if they would be good markers of benign prostate in tissue. Here, ACOXL is linked to prostate cancer.