A number of other clinical trials are ongoing with SRC inhibitors to evaluate bone turnover markers as a specified endpoint in addition to tumour responses in breast cancer, including randomized phase II studies with exemestane [71] or letrozole administered with or without dasatinib [72], a randomized phase II study of fulvestrant with or without dasatinib [73], a phase I/II study of dasatinib in combination with zoledronic acid [74] and a phase II study of dasatinib administered either once or twice daily in patients with breast cancer and bone metastases [75]. The gene discussed is SRC; the disease is breast carcinoma.