Analyzing signaling distributions in DO11.10 T cell:A20 B cell lymphoma cell conjugates (S2O–S2Q Fig) for corroboration with a subset of 21 sensors, we found that SLP-76, PIP2, Vav, α-Pix and Myosin 1C displayed prominent lamellal localization as in 5C.C7 T cells. Here, ARHGEF6 is linked to B-cell non-Hodgkin lymphoma.