The authors of this study therefore proposed that DICER1 was an important negative regulator of NLRP3 inflammasome activation in RPE and that genetic or pharmacological inhibition of inflammasome components or MyD88 might prevent RPE degeneration due to DICER1 loss or Alu RNA exposure in dry AMD [49]. The gene discussed is DICER1; the disease is dry age related macular degeneration.