Interestingly, NLRP3 inflammasome activation by C1Q was dependent on phagolysosome activity and cathepsin B. We also detected NLRP3 and cleaved caspase-1 in activated macrophages in the retina after immunization of mice with CEP-adducted mouse serum albumin to model a dry AMD-like pathology, however, we did not determine whether this contributed to the pathology observed in this mouse model. Here, NLRP3 is linked to dry age related macular degeneration.