The combination of the Type I and Type II mutations does not seem to be completely random; specific combinations seem more prevalent, such as the Ras pathway mutations, which are often found in combination with MLL-rearrangements, KIT mutations, which are mainly found in CBF-AML, and FLT3-itd, which is often seen in combination with PML/RARA and NUP98/NSD1 (Figure 1) [48,57]. This evidence concerns the gene KMT2A and acute myeloid leukemia.