KMT2A and acute myeloid leukemia: The most common cytogenetic abnormalities (Type II) in children are t(8;21)(q22;q22), inv(16)(p13.1q22) (together referred to as core binding factor (CBF)-AML), t(15;17)(q22;q21) and 11q23/MLL-rearranged abnormalities (Figure 1A) [49,50,51,52].