Evans has tested the adoptive transfer of B cells into mice immunized with bovine collagen (type II collagen) inhibits TH1 responses, prevents arthritis development, and is effective in ameliorating established disease, while the adoptive transfer of CD21hiCD23+IgM+ B cells from DBA/1 mice in the remission phase could prevents CIA and reduces disease severity through IL-10 secretion [22]; Gu also found a substantial reduction in the number of TH17 cells [43]. This evidence concerns the gene IL10 and arthritic joint disease.