BRCA1 and cancer: It is argued that BRCA1/2 mutation screening may be of greater relevance to females as the risks of cancer are greatly elevated in female BRCA1/2 mutation carriers compared to male [37], however the findings of this review highlight that there are cancer risks for male carriers of BRCA1/2 mutations therefore screening has relevance for men in their own right, rather than just to inform risk for relatives.