Restoration of hypothalamic SIRT1 function can prevent age-associated weight gain in mice, indicating that improving hypothalamic SIRT1 function at multiple levels via supplementation with NAD+ intermediates, SIRT1 activators, and a SIRT1 “booster” may enable novel treatments of weight gain related to metabolic syndromes as well as weight gain caused by aging (Figure 6). This evidence concerns the gene SIRT1 and metabolic syndrome.