SRF and cerebral amyloid angiopathy: The overexpression profile of SRF/MYOCD initiates a hypercontractile phenotype in the cerebral arteries through increased expression of SRF/MYOCD-regulated contractile proteins, thereby resulting in cerebral hypoperfusion, diminished neurovascular coupling and cerebral amyloid angiopathy (CAA; Chow et al., 2007).