Reductions in glucose transporters observed in AD (Kalaria and Harik, 1989; Horwood and Davies, 1994; Simpson et al., 1994; Mooradian et al., 1997), extends its effects beyond apparent hypometabolism to essentially affect Aβ clearance mechanisms by regulating LRP1 levels in the cerebral endothelia. Here, LRP1 is linked to Alzheimer disease.