ApoE interacts with Aβ and plays an important role in its metabolism and AD pathogenesis (Wisniewski and Frangione, 1992; Holtzman et al., 2000; DeMattos et al., 2004; Bell et al., 2007; Deane et al., 2008; Jiang et al., 2008; Castellano et al., 2011; Zlokovic, 2013; Tai et al., 2014). This evidence concerns the gene APOE and Alzheimer disease.