KCNC1 and progressive myoclonus epilepsy: More recently, a recurrent mutation in the KCNC1 gene, encoding for Kv3.1 channels, has been identified in patients with Progressive Myoclonus Epilepsy (PME7; OMIM 616187; Muona et al., 2015), one of the most devastating form of epilepsy, characterized by a very wide clinical and genetic heterogeneity (Berkovic et al., 1986).