Alterations of GABAergic interneurons in Nav1.1−/− mice could also contribute to explain additional clinical manifestations occurring in SMEI patients: in fact, Nav1.1+/− mice have a reduced non-REM sleep, impaired circadian behavior, cognitive impairment and autistic-like traits, reminiscent of those observed in children with SMEI (Han et al., 2012). Here, SCN1A is linked to Cognitive impairment.