In addition to BFNIS, de novo dominant mutations in SCN2A can cause also more severe seizure syndromes (Kamiya et al., 2004; Ogiwara et al., 2009; Liao et al., 2010a; EIEE11; OMIM 613721): as recently reviewed (Baasch et al., 2014), 14 mutations in Nav1.2 appear to relate with BFNIS and 21 mutations with more severe phenotypes, including developmental delay and intractable seizures. Here, SCN2A is linked to Benign familial neonatal-infantile seizures.