In addition, de novo missense Kv7.2 mutations have been recently found in neonates affected with pharmacoresistant seizures, distinct EEG and neuroradiological features, and various degrees of developmental delay, defining a “Kv7.2 encephalopathy” (Weckhuysen et al., 2012; EIEE7; OMIM 613720). The gene discussed is KCNQ2; the disease is Global developmental delay.