Two additional Nav1.1 mutations not affecting the VSM but rather the DIII-DIV linker (Q1498H and F1499L) can also cause Elicited Repetitive Daily Blindness (ERDB), suggesting that SCN1A mutations can cause a complex spectrum of human disease, including epilepsy, FHM3 and/or retinal cell excitability (Vahedi et al., 2009). This evidence concerns the gene SCN1A and epilepsy.