Mutations in KCNT1 gene have been identified in patients with two different type of epilepsy occurring in infancy or childhood: Malignant Migrating Partial Seizures of Infancy (MMPSI; also called Epilepsy of Infancy with Migrating Focal Seizures, EIMFS) and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE; Barcia et al., 2012; Heron et al., 2012). This evidence concerns the gene KCNT1 and malignant migrating partial seizures of infancy.