AKT2 and neoplasm: Selective silencing of Akt2 reduced LNM35 tumor volume by 23.7% (2810.1 mm3 +/−687.4, p = 0.29), compared with LNM35 cells transfected with control-siRNA (3683 mm3 +/−405.6) as measured five weeks after tumor cell injection (Fig. 4A).