SPP1 and colorectal carcinoma: Fig. S5a determined that tumor grade was correlated with OPN expression detected by IHC (OR 2.33, 95% CI 1.60–3.41). Moreover, OPN expression detected by IHC or RT-PCR was significantly related to 5-year survival rate and overall survival of patients with CRC in Fig. S5b and Fig. S5c.