SPP1 and colorectal cancer: Fig. 4 exhibited that high OPN expression was significantly associated with the 2-year (HR 1.97, 95% CI 1.30–3.00), 3-year (HR 1.82, 95% CI 1.24–2.68), and 5 year (HR 1.53, 95% CI 1.28–1.82) survival rates in colorectal cancer patients, respectively.