The sensitivity and specificity in differentiating DLB from AD were 72.4 and 94.4 % by the H/M ratio of MIBG uptake in the delayed phase, 88.2 and 88.9 % by the SBR on DAT SPECT, and 96.1 and 90.7 % by the DAT*MIBG index, respectively. This evidence concerns the gene SLC6A3 and Alzheimer disease.