ZMPSTE24 and laminopathy: Second, we demonstrated that the GMF-TG mice showed a reduced expression of the cleaving enzyme of prelamin A (Zmpste24) in the kidney tissue, from an earlier stage of life (Figure 6C and D), suggesting that the GMF-TG mice would probably be affected by secondary laminopathy [16] due to an accumulation of prelamin A, accompanied by a reduction in the expression of Zmpste24.