PCK1 and Insulin resistance: Consistent with the assumption of a hepatic insulin resistance, the expression of proteins involved in glucose homeostasis, such as glucose-6-phosphatase (encoded by G6pc) and phosphoenolpyruvate carboxykinase1 (encoded by Pck1), was significantly increased in livers of B6-Tg(Zfp69) mice at week 24 (ESM Fig. 5).