Compared with normal cycling women, miR-10a-5p, miR-1307-3p, miR-423-5p, miR-1273 g-3p, miR-199a-3p, miR-185-5p, and miR-483-5p are upregulated in the CGCs of PCOS patients, and miR-483-5p suppresses Notch3 and mitogen-activated protein kinase 3 (MAPK3) expression in human CGCs by directly binding the 3′-UTRs of Notch3 and MAPK3 mRNA [27]. The gene discussed is NOTCH3; the disease is polycystic ovary syndrome.