We and others have documented the pro- and/or anti-inflammatory effects and neurotoxic or neuroprotective properties of signaling through the PGE2-EP1 axis in various models of acute and chronic neurological disorders such as stroke, hypoxic-ischemic encephalopathy (HIE), traumatic brain injury (TBI), AD, and PD [10, 11, 14, 15, 24, 28, 30–32]. The gene discussed is PTGER1; the disease is Alzheimer disease.