In our study, nab-paclitaxel caused high levels of mitotic arrest over a larger area after local injection into tumors than CrEL-paclitaxel and DMSO-paclitaxel, strongly supporting albumin-mediated enhancement of paclitaxel tissue penetration and tumor cell uptake, which likely contributes to the increased antitumor effect of nab-paclitaxel over solvent-based paclitaxel in preclinical and clinical studies. The gene discussed is ALB; the disease is neoplasm.