KLK6 and central nervous system cancer: In this regard it is of interest that not only are levels of KLK6 significantly elevated in high-grade glioma (glioblastoma multiforme (GBM), grade IV astrocytoma) and associated with poor patient survival, but in addition KLK6 promotes the resistance of glioma cells to a wide variety of cell death-inducing agents, including staurosporine, cisplatin, radiation and temozolomide [5].