CXCL1 and metabolic dysfunction-associated steatohepatitis: In our study, we found that osthole treatment downregulated TAA-induced mRNA levels of tnf-α, interleukin-1β, and inos. Reports have shown CXCL1 is genetic risk factors involved in the pathogenesis of NASH and alcoholic cirrhosis, and CXCL1 is a ligand for CXC chemokine receptor family expressed on HSCs [49, 50].