Despite some noise interfered the COX-2 promoter activity by structural proteins under JFH-1 infection (S2 Fig), we found the most significant activation of COX-2 promoter contain C/EBP binding site with NS5A-expressing Huh7 cells and in replicon cells by comparison of relative change of induction fold of reporter activity (Fig 5E). Here, PTGS2 is linked to infection.