TNNI3 and limb ischemia: Another recent meta-analysis [4] of 19 randomized clinical trials involving 1,235 patients showed a statistically significant reduction in cardiac troponin I (cTnI) release at 6 hours post-operatively and in total cTnI release after cardiac surgery in patients who received remote ischemic preconditioning through limb ischemia versus control group (weighted mean difference -2.03ug/L, 95% CI -3.25 to -0.82ug/L, p for effect = 0.001; weighted mean difference -65.74ug/L*h, 95% CI -107.88 to -23.61ug/L*h, p for effect = 0.002, respectively), but with no differences in mortality.