The genetic landscape and its prognostic relevance have been explored in CMML.25, 26, 27, 28 It is recognized that nonsense and frame-shift mutations of ASXL1 are adversely prognostic, and the presence of these mutations has now been incorporated in two distinct CMML prognostic models.14, 15 As such, we wished to explore the prognostic significance of ASXL1 and other recurrent genetic mutations in our data set. This evidence concerns the gene ASXL1 and chronic myelomonocytic leukemia.