Encouragingly as expected, mutational frequencies and mutual exclusivities in signaling mutations in these representative subgroups were similar to those reported from other published cohorts.7, 12, 28 After confirming this, we explored the prognostic relevance of ASXL1 (n=561), TET2 (n=369), SRSF2 (n=487), RUNX1 (n=377), EZH2 (n=323), NRAS (n=367), CBL (n=374) and JAK2 (n=789) in all evaluable cases comprising the most frequently mutated genes in CMML. The gene discussed is JAK2; the disease is chronic myelomonocytic leukemia.