Somatic mutation of the tumor suppressor gene, TP53, located in 17p13 is one of the most frequent alterations in cancer.1, 2 The TP53 protein exerts its tight regulation of apoptosis and cell cycle integrity, and inactivation of TP53 may lead to uncontrolled cell proliferation and promote cancer development.3, 4 The frequency of TP53 mutation is usually increased in the patients with advanced stages or aggressive types of cancers.5, 6. This evidence concerns the gene TP53 and cancer.