To better stratify AML patients into different risk groups, a survival scoring system incorporating TP53 mutation and nine other prognostic factors, including age, WBC counts, cytogenetics, NPM1/FLT3-ITD, CEBPA, IDH2, RUNX1, WT1 and DNMT3A mutations, into survival analysis was formulated. The gene discussed is RUNX1; the disease is acute myeloid leukemia.