For example, IL-10 downregulates proinflammatory cytokine expression and acts as an antitumoral cytokine.17, 18 In contrast, IL-10 also suppresses antigen-presenting cells thereby allowing tumor cells to evade immune surveillance mechanisms.17, 19, 20 In B-cell NHL, it has been shown that serum levels of IL-10 are elevated and elevated levels are associated with an inferior prognosis.21, 22, 23 We therefore wished to determine whether IL-10 has a role in regulating the function of monocytes and in defining their phenotype and function. This evidence concerns the gene IL10 and neoplasm.