E2F1 and neoplasm: High expression of RAD51 and E2F1 also correlated with clinico-pathological features, and was associated with young age at onset (p = 0.002), a trend toward lymph node involvement at diagnosis (p = 0.08) and markers of aggressive disease, i.e. high tumor grade, lack of estrogen and progesterone receptor expression, Her2 amplification and ki67 staining (Table 1).