High expression of RAD51 and E2F1 also correlated with clinico-pathological features, and was associated with young age at onset (p = 0.002), a trend toward lymph node involvement at diagnosis (p = 0.08) and markers of aggressive disease, i.e. high tumor grade, lack of estrogen and progesterone receptor expression, Her2 amplification and ki67 staining (Table 1). This evidence concerns the gene MKI67 and neoplasm.