LUM and cancer: Hence, according to the studies abovementioned and the proof-of-concept of the known SLRP anticancer activity, DCN and LUM could play dual microenvironment-dependent roles in the maintenance of CSCs, inhibiting the growth of epithelial-like proliferative cells, but concomitantly promoting the survival and stem-like properties of residual CSC-like, including TMZ resistance, quiescence, and the maintenance of heterogenic cancer cell phenotypes.