Moreover, SLRP+ NB and GBM CSC-like isolated from the neurospheres showed lower proliferation rates, less apoptosis, and greater drug resistance than the parental cell lines, suggesting pivotal and synergistic roles for DCN and LUM in the TMZ resistance, survival, and maintenance of quiescent, slow-cycling, CSC-like subpopulations. Here, DCN is linked to glioblastoma.