HOOK3 proved to be an independent prognosticator irrespective of the tested scenario or subgroup (all cancers: p = 0.0003 in scenario 1, p<0.0001 in scenario 2–4; ERG negative cancers: p = 0.0002 in scenario 1, p<0.0001 in scenario 2–4; ERG positive cancers: p = 0.0381 in scenario 1, p = 0.0433 in scenario 2, p = 0.0006 in scenario 3, p<0.0001 in scenario 4). This evidence concerns the gene ERG and cancer.