The contribution of Ang II to the pathogenesis of hypertension, cardiac hypertrophy and heart failure, alongside with Ang II role in body fluids homeostasis [9, 10], and the previously published existence of Ang II receptors in AEC II[11], led us to investigate the role of Ang II on AFC in AEC II, and the molecular mechanisms by which Ang II exerts its effect on AFC. The gene discussed is AGT; the disease is hypertensive disorder.