ALS has two types: familial ALS (fALS) caused by genetic mutations, including superoxidase dismutase 1 (SOD1), alsin, senataxin, angiogenin, VAMP-associated protein B, dynactin, transactive response (TAR) DNA-binding protein 43 (TDP43), fused in sarcoma (FUS) and C9ORF72; and sporadic ALS (sALS), which includes ninety percent of all ALS cases and is induced by various environmental and genetic factors. This evidence concerns the gene SETX and amyotrophic lateral sclerosis.