Among these, a human polymorphic variant in the NADH dehydrogenase 3 (ND3) gene at nt 10,398 (nt G10398A) that alters the structure of Complex I in the mitochondrial ETC was associated with an increased risk for invasive breast cancer in African–American women [38,41], the A12308G mutation in tRNALeu(CUN) was associated with increased risk of both renal and prostate cancers [42], and a variant in a non-coding region of mtDNA (16189T>C) was associated with increased susceptibility to endometrial cancer [43]. This evidence concerns the gene MT-ND3 and Familial prostate cancer.