CALR and systemic lupus erythematosus: In particular, in 2009, Zandman-Goddard et al. have shown a significant association between elevated antibodies against Epstein-Barr virus (EBV) and skin and joint symptoms in SLE patients and that exposure to EBV infection may predict a disease phenotype of mild SLE with cutaneous and articular manifestations and elevated titers of anti-Ro antibodies [13].