Individuals carrying the DRB1*12:01 allele have been reported to produce a high level of immune antibodies against Plasmodium falciparum asexual-stage apical membrane antigen 1 (AMA1).[44] However, individuals carrying DRB1*15 only produce a low level of antibodies against the malaria vaccine SPF66. The gene discussed is HLA-DRB1; the disease is malaria.