However, in certain mouse models for diseases such as allergic airway inflammation induced by intraperitoneal immunization with OVA [10, 18, 19], collagen-induced arthritis [20, 21] and LPS-induced septic shock [18, 36], distinctly different immune responses were observed between ST2-/- mice and IL-33-/- mice. The gene discussed is IL1RL1; the disease is Shock.