The statistics of the Swiss HIV Cohort Study (SHCS), in which significant proportions of the HIV-infected individuals in Switzerland participate, namely 53% of the patients with an HIV notification and 69% of the patients with an AIDS notification to the SFOPH, show that the median CD4+ T-cell count at the initiation of ART in treatment-naïve patients has constantly increased in recent years, particularly among MSM. The gene discussed is CD4; the disease is AIDS.