In contrast to psoriasis, the typical cytokine expression pattern of AD is characterized by a local increase of IL-4, IL-5, IL-13, TSLP, and IgE, driving DC to induce a biphasic T cell profile by the secretion of chemotactic factors, involved in Th2 recruitment and the release of Th2/Th1-polarizing cytokines in chronic lesions [126]. Here, IGHE is linked to Alzheimer disease.